Pesticides / Biocides

 
Quality Assurance System: Good Laboratory Practice (GLP)

Analytical methods

  • Determination of content of active substance (SANCO/3030/99 rev. 4)
  • Analytical method validation (SANCO/3030/99 rev. 4)
  • Five batch analysis (SANCO/3030/99 rev. 4)

Physico-chemical tests

  • Spectral data (MS, NMR, IR, UV/VIS)
  • State of substance (20 °C and 101.3 kPa)
  • Melting/freezing point (EU A.1/OECD 102)
  • Boiling point (EU A.2/OECD 103)
  • Relative density (EU A.3/OECD 109)
  • Vapour pressure (EU A.4/OECD 104)
  • Water solubility (EU A.6/OECD 105)
  • Partition coefficient n-octanol/water (EU A.8/OECD 107 + OECD 117)
  • Flash point (EU A.9)
  • Surface tension (EU A.5/OECD 115)
  • Explosive properties (EU A.14)
  • Oxidizing properties (EU A.17)
  • Solubility in organic solvents (CIPAC MT 181)
  • Dissociation constant (OECD 112)
  • Viscosity (EN ISO 3140) and other…

Toxicological studies

  • Acute oral toxicity - fixed dose procedure (OECD 420)
  • Acute oral toxicity - acute toxic class method (OECD 423)
  • Acute toxicity (dermal; OECD 402)
  • In vitro skin corrosion: human skin model test (OECD 431)
  • In vitro skin irritation (OECD 439)
  • Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants (OECD 437)
  • Local lymph node assay (OECD 429)
  • Guinea pig maximisation test (OECD 406)
  • Repeated dose (28-days) toxicity (oral; OECD 407)
  • Sub-chronic oral toxicity test (repeated dose 90-days oral toxicity study in rodents; OECD 408) 
  • Chronic toxicity test (OECD 452) 
  • Combined chronic toxicity/carcinogenicity studies (OECD 453) 
  • Reverse mutation test using bacteria (OECD 471) 
  • In vitro mammalian cell micronucleus test (OECD 487) 
  • In vitro mammalian chromosome aberration test (OECD 473) 
  • In vitro mammalian cell gene mutation test (OECD 476) 
  • In vivo mammalian erythrocyte micronucleus test (OECD 474) 
  •  Prenatal developmental toxicity study (OECD 414) 
  • Two-generation reproduction toxicity test (OECD 416) 

Ecotoxicological studies

  • Acute toxicity for fish (OECD 203) 
  • Daphnia magna, acute immobilisation test (OECD 202) 
  • Algal inhibition test (OECD 201) 
  • Activated sludge respiration inhibition test (OECD 209) 
  • Daphnia magna reproduction test (OECD 211) 

Fate and behaviour in the environment 

  • Hydrolysis as a function of pH (EU C.7) 
  • Estimation of the adsorption coefficient (KOC) on soil and on sewage sludge using HPLC (EU C.19/OECD 121)  
  • Ready biodegradability - Closed bottle test (OECD 301D) 
  • Biodegradation - Zahn-Wellens test (EU C.9/OECD 302B) 

and other...